Project Title

Purification of Ethyl Diazoacetate by Vacuum Distillation for use in Cyclopropanation Reactions

Authors' Affiliations

Ayobami Olukanni, Department of Chemistry, College of Arts and Sciences, East Tennessee State University, Johnson city, TN Cassandra Eagle, Department of Chemistry, College of Arts and Sciences, East Tennessee State University, Johnson city, TN Ray Mosheni, Department of Chemistry, College of Arts and Sciences, East Tennessee State University, Johnson city, TN Adesina Olumide,Department of Chemistry, College of Arts and Sciences, East Tennessee State University, Johnson city, TN

Location

BEECH MTN. ROOM 120

Start Date

4-12-2019 1:20 PM

End Date

4-12-2019 1:35 PM

Faculty Sponsor’s Department

Chemistry

Name of Project's Faculty Sponsor

Dr. Cassandra Eagle

Faculty Sponsor's Department

Chemistry

Type

Oral Presentation

Classification of First Author

Graduate Student-Master’s

Project's Category

Chemicals and Chemical Properties

Project's Category

Arts and Humanities

Abstract Text

Environmentally friendly insecticides have long been desired in the production of food. Pyrethiod compounds not only decompose under light and heat, but they are highly toxic to insects while having effectively no toxicity to mammals. The cis-cyclopropane ring in pyrethiod insecticides is the most challenging component to synthesize. We are exploring the best parameters for the most effective cis-Cyclopropanation reactions. An alkene and a diazo compound react together in the presence of a dirhodium catalyst to produce cyclopropanes. First however, the starting materials must be pure. My part of the project is to purify ethyl diazoacetate(EDA). Column chromatography has been used, but yielded no fraction containing EDA as determined by Gas chromatography/Mass spectrometry. Extraction of EDA with sodium carbonate solution yielded similar results. Thus, I turned to distillation at reduced pressure. This method produced EDA in high enough purity to be used in cyclopropanation reactions. The purity of EDA was determined by H-1 nuclear magnetic resonance spectroscopy.

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Apr 12th, 1:20 PM Apr 12th, 1:35 PM

Purification of Ethyl Diazoacetate by Vacuum Distillation for use in Cyclopropanation Reactions

BEECH MTN. ROOM 120

Environmentally friendly insecticides have long been desired in the production of food. Pyrethiod compounds not only decompose under light and heat, but they are highly toxic to insects while having effectively no toxicity to mammals. The cis-cyclopropane ring in pyrethiod insecticides is the most challenging component to synthesize. We are exploring the best parameters for the most effective cis-Cyclopropanation reactions. An alkene and a diazo compound react together in the presence of a dirhodium catalyst to produce cyclopropanes. First however, the starting materials must be pure. My part of the project is to purify ethyl diazoacetate(EDA). Column chromatography has been used, but yielded no fraction containing EDA as determined by Gas chromatography/Mass spectrometry. Extraction of EDA with sodium carbonate solution yielded similar results. Thus, I turned to distillation at reduced pressure. This method produced EDA in high enough purity to be used in cyclopropanation reactions. The purity of EDA was determined by H-1 nuclear magnetic resonance spectroscopy.