Honors Program
[Honors-in-Discipline (Choose below)], Honors in Health Sciences: Microbiology
Date of Award
5-2020
Thesis Professor(s)
Sean Fox
Thesis Professor Department
Health Sciences
Thesis Reader(s)
Lindsey King, Laraine Powers
Abstract
Candida albicans is a fungal microorganism found on the human body and in the environment. An opportunistic pathogen causing local and systemic infection, this fungus is one of the leading causes of nosocomial infections. More alarming is its growing resistance against the limited number of antifungals we have for treatment Candida infections. An area of current research, termed polymicrobial interactions, focuses on how different microorganisms interact with each other for limited space, nutrients, and survival. The current study focuses on attempting to inhibit planktonic and biofilm growth stages by using the benign bacterium Alcaligenes faecalis, previously shown in our lab to kill C. albicans. Under a variety of growth conditions and phases, co-cultures of A. faecalis and C. albicans have demonstrated that the bacterium drastically inhibits all forms of Candida growth. The results of this study may provide information on potential new therapeutic targets that Alcaligenes may employ in inhibition of Candida.
Publisher
East Tennessee State University
Document Type
Honors Thesis - Open Access
Creative Commons License
This work is licensed under a Creative Commons Attribution-Noncommercial-No Derivative Works 3.0 License.
Recommended Citation
Siddiqui, Nausheen A., "The Effect of Alcaligenes faecalis on Inhibition of Candida albicans Biofilm and Planktonic Growth" (2020). Undergraduate Honors Theses. Paper 575. https://dc.etsu.edu/honors/575
Copyright
Copyright by the authors.