PhD (Doctor of Philosophy)
Date of Award
Committee Chair or Co-Chairs
Meredith K. Ginley
Robert P. Pack, Kelly E. Moore, Gerald A. Deehan
There is an established bidirectional relation between substance use and traumatic brain injuries (TBIs). Despite the high rate of prescribing opioids for pain management following a TBI and the epidemic of opioid use disorder (OUD) in the United States, scarce research has specifically analyzed the association between TBI and OUD. In a series of three interrelated manuscripts, the present study will first examine the prevalence and features of TBIs among persons seeking treatment for OUD. Next, the present study will evaluate the association between TBI and indicators of risky health behaviors and OUD severity, including the risk of overdose and polysubstance use. The predictive ability of symptoms of posttraumatic stress disorder, anxiety, impulsivity, depression, and chronic pain on odds of having had a TBI will also be calculated. Last, a systematic review will be conducted to provide comprehensive guidelines for effective methods of tailoring OUD treatment to mitigate the effects of TBI on treatment outcomes. Altogether, the findings will aid in the understanding of the development of TBI for persons with OUD, provide insight into common clinical complexities for patients with OUD and TBI, and offer guidance on how best to tailor interventions to increase substance use treatment efficacy for persons with TBI.
Dissertation - unrestricted
Mitchell, Hannah G., "The Implications, Magnitude, and Development of Traumatic Brain Injury for Individuals Undergoing Treatment for Opioid Use Disorder" (2024). Electronic Theses and Dissertations. Paper 4247. https://dc.etsu.edu/etd/4247
Copyright by the authors.