MS (Master of Science)
Date of Award
Committee Chair or Co-Chairs
Jennifer Hall, Bert Lampson
A rising problem in agriculture is the increase of antibiotic-resistant Salmonella cases associated with chicken eggs, which transmit infection to humans. To counter this, new approaches to combat Salmonella in chickens and desiccated on eggshells are vital in the prevention of human foodborne illness. Disrupting signaling pathways with naturally occurring compounds provides a potential novel avenue for prevention of Salmonella infections, as this would disrupt sensing of these environments and inhibit subsequent optimal gene expression. Starting with signals identified in previous studies, salicylic acid was found to inhibit Salmonella desiccation survival on both eggshells and plastic. To expand upon this, a desiccation inhibition screen of 285 signals resulted in 9 additional potential desiccation inhibitors, including deoxyribose and guanine. By using natural signals to disrupt bacterial communication pathways, novel therapeutics that serve as viable antibacterial alternatives could be developed to prevent Salmonella contamination at a major source.
Thesis - embargo
Headrick, Joseph, "Inhibiting Survival of Salmonella During Desiccation Through the Use of Naturally Occurring Signals" (2023). Electronic Theses and Dissertations. Paper 4210. https://dc.etsu.edu/etd/4210
Copyright by the authors.
Available for download on Saturday, June 15, 2024