Degree Name

MS (Master of Science)

Program

Chemistry

Date of Award

12-2019

Committee Chair or Co-Chairs

Dr. Hua Mei, Ph.D.

Committee Members

Dr. Cassandra Eagle, Ph.D., Dr. Catherine McCusker, Ph.D.

Abstract

Carbon dots (CDs) have attracted much attention as an excellent gene/drug delivery and biological imaging agent for early cancer theranostics. In this study, we prepared two series of nanoparticles (NPs), which are composed of (CDs) with a targeting agent, folic acid (FA), and a chemotherapeutic agent Doxorubicin (Dox). All the NPs and their intermediates were characterized using ultraviolet-visible spectroscopy (UV-vis), fluorescence spectroscopy, and Fourier transform-infrared spectroscopy (FT-IR). The drug loading capacity (DLC) and drug loading efficiency (DLE) of two series of FA-CDs-Dox were assessed using UV-vis absorption spectroscopy at the wavelength of 485 nm. Both showed good DLE and DLC results when compared to literature data. In addition, the cumulative release property of Dox from the FA-CDs-Dox complexes were investigated in a pH solution of 7.4.

Document Type

Thesis - Withheld

Copyright

Copyright by the authors.

Available for download on Sunday, November 12, 2023

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