Degree Name
MS (Master of Science)
Program
Chemistry
Date of Award
12-2019
Committee Chair or Co-Chairs
Dr. Ismail O. Kady
Committee Members
Dr. Abbas G. Shilabin, Dr. Catherine McCusker
Abstract
Hydroxytyrosol is one of the most powerful known antioxidants. It is a naturally occurring polyphenol, most commonly produced in olive trees, (Olea europaea). The remarkable antioxidant and pharmacological properties of hydroxytyrosol has made it an outstanding compound in the polyphenol family and of great interest to many researchers. Hydroxytyrosol can scavenge free radicals produced during cellular oxidative stress and helps to protect the integrity of cells in living systems. Despite its numerous biological and pharmacological uses, it is found in very low concentration in olive oil, this limits its availability for biomedical applications. This work reports a novel and effective method for synthesizing hydroxytyrosol from the readily available precursor catechol. The cellular uptake of hydroxytyrosol is slow due to its high hydrophilicity. Therefore, this research aimed at synthesizing less hydrophilic derivatives of hydroxytyrosol by introducing some selected hydrophobic groups (such as alkyl, acyl, …) to its molecular skeleton.
Document Type
Thesis - unrestricted
Recommended Citation
Ametsetor, Ebenezer, "Synthesis and Study of Hydroxytyrosol Derivatives" (2019). Electronic Theses and Dissertations. Paper 3643. https://dc.etsu.edu/etd/3643
Copyright
Copyright by the authors.