MA (Master of Arts)
Date of Award
Committee Chair or Co-Chairs
Russell W. Brown
Otto Zinser, Michael L. Woodruff
Rats were administered nicotine (0.3 mg/kg) for 11 consecutive days before and after an electrolytic medial frontal cortex lesion. Behavioral testing was arranged so that the rats were tested on the RAM 1 day after drug administration followed by behavioral testing on the MWT 19 days after drug treatment, or tested on the MWT 1 day after drug administration followed by testing on the RAM4 days after drug treatment. Results of MWT testing showed that regardless of the drug/behavioral testing interval, lesioned rats given nicotine demonstrated enhancement relative to saline-treated animals. Results of RAM testing showed that nicotine improved performance in non-lesioned rats compared to non-lesioned rats given saline. Four days after drug administration, nicotine improved performance in lesioned rats to levels of non-lesioned rats regardless of drug treatment. A second experiment was implemented to determine if the previous training on the MWT affected performance on the RAM.
Thesis - Open Access
Norris, Rachel L., "Previous Spatial Memory Training and Nicotine Administration Alleviates Cognitive Deficits Produced by Medial Frontal Cortex Lesions in Rats." (2006). Electronic Theses and Dissertations. Paper 2190. https://dc.etsu.edu/etd/2190
Copyright by the authors.