MA (Master of Arts)
Date of Award
Committee Chair or Co-Chairs
Russell W. Brown
Michael L. Woodruff, Wallace E. Dixon Jr.
This study investigated nicotine conditioned place preference (CPP) in two different ages of adolescence using a rodent model of schizophrenia. Both 2- and 3-chambered CPP apparatuses were used to test whether the CPP was due to an aversion to the white chamber. Animals were neontally treated with the dopamine D2/D3 agonist, quinpirole, or saline and raised to either early postweanling age (P 22) or adolescence (P 29). Rats were conditioned to prefer the white chamber using nicotine. Results showed that nicotine induced CPP and appeared to alleviate an increased stress response in D2 primed animals, which appeared to diminish over time. Additionally, adult D2 and non-D2 primed rats were tested on the elevated T-maze. Results revealed that D2 primed rats demonstrated a significant increase in unconditioned fear. This study showed that nicotine induced CPP in D2 and non-D2 primed rats regardless of age, and D2 primed rats appear to demonstrate an increase in stress levels that was alleviated by nicotine.
Thesis - unrestricted
Ogawa, Yoko Emily, "The Effects of Nicotine Conditioned Place Preference in D2 Primed Adolescent Rats: Age-Related and Gender Effects." (2007). Electronic Theses and Dissertations. Paper 2129. https://dc.etsu.edu/etd/2129
Copyright by the authors.