MPH (Master of Public Health)
Date of Award
Committee Chair or Co-Chairs
Joel J. Hillhouse, Tiejian Wu
Conduct disorder (CD) is a psychiatric syndrome in childhood and adolescence that is one of the most common childhood disorders with continuously increasing prevalence but uncertain pathogenesis. We performed a genome-wide, family-based association study of CD using P2BAT/FBAT software. The data is gathered from Collaborative Study on the Genetics of Alcoholism (COGA) and International Multi-Center ADHD Genetics Project (IMAGE).
Using COGA data, we identified 20 markers which showed suggestive associations (p<10-3) with CD. Nine of them are located in known genes. Two genes, ADAM10 and CAMK2A, which had been reported associated with Alzheimer's disease (AD), bipolar disorder, and depression, were of more concern. Using IMAGE sample, our results were well replicated.
This study identified several CD associated genetic variants, especially two novel candidate genes. These findings may serve as a resource for replication in other populations to elucidate the potential role of these genetic variants in CD.
Thesis - Open Access
Jian, Xueqiu, "A Family-Based Association Study of Conduct Disorder." (2010). Electronic Theses and Dissertations. Paper 1697. https://dc.etsu.edu/etd/1697
Copyright by the authors.