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MS (Master of Science)
Date of Award
Committee Chair or Co-Chairs
Ismail O. Kady
Yu-Lin Jiang, Chu-Ngi Ho
Photodynamic Therapy (PDT) of cancer involves radiating photosensitizing drugs with light in tumors, which results in generating active singlet oxygen that kills cancer cells. Photosensitizers currently used in PDT are of low quantum yield and require high energy radiation, normally laser. Therefore there is always need for more effective PDT drugs. In this project we synthesized new derivatives of phenothiazinium for potential applications in PDT. Phenothiazinium was synthesized and derivatized by linking it to side groups containing imidazole rings. These derivatives are also expected to catalyze certain hydrolytic reactions. Such ôhydrolase modelsö use molecular recognition based on ??? stacking between the phenothiazinium ring and aromatic rings of specific substrates, such as anthracene monophosphate, while imidazole groups catalyze the hydrolysis of the phosphate ester by general acid-base mechanism.
Thesis - restricted
Mehraban, Nahid, "Synthesis of Phenothiazinium Derivatives" (2012). Electronic Theses and Dissertations. Paper 1464. https://dc.etsu.edu/etd/1464
Copyright by the authors.