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MS (Master of Science)
Date of Award
Committee Chair or Co-Chairs
William L. Stone
Thomas T. S. Huang, Jeffrey G. Wardeska
This research, focusing mainly on tocotrienols, includes two parts. The first part concerns the uptake and growth inhibition of tocotrienols in PC-3 cells. The second part is a study of the physiochemical properties of Vitamin E.
In the cellular study our results suggested that position 5 of chroman head and side-chain are very important in determining the uptake of tocotrienols and growth inhibition of PC-3 cells. The uptake and growth inhibition are not necessarily related to the antioxidant properties of tocotrienols.
Of the physiochemical studies, the results suggested that the antioxidant properties of vitamin E are due to the phenolic O-H group. In ethanol solution, each tocotrienol has a higher oxidation potential than its corresponding tocopherol. The oxidation potentials of vitamin E are in the order ofα-form < γform < δ-form. The theoretical calculations show that the side chains of tocotrienols are less ordered than those of tocopherols.
Thesis - Campus Only
Zuo, Tianming, "The In Vitro Cellular Uptake and Physiochemical Properties of Tocotrienols." (2003). Electronic Theses and Dissertations. Paper 780. http://dc.etsu.edu/etd/780
Copyright by the authors.