Degree Name
MS (Master of Science)
Program
Chemistry
Date of Award
8-2013
Committee Chair or Co-Chairs
Dr. Cassandra Eagle
Committee Members
Dr. Ismail Kady, Dr. Aleksey Vasiliev
Abstract
Resveratrol is a naturally occurring phytoalexin of the stilbene family produced by various plants in response to stress, UV radiation, and fungal attack. It is primarily found in peanuts, berries, grape skin, and red wine. Resveratrol has been found to exhibit anti-cancer, anti-inflammatory, anti-aging, and anti-oxidant properties. Research indicates that diets enriched with resveratrol containing substances result in less incidence of cancer. Unfortunately, the low bioavailability and solubility has been a huge setback for its potential prospects. As a result, efforts have been made to synthesize derivatives of resveratrol with increased solubility and bioavailability. Three triester novel resveratrol derivatives 3, 4’, 5-tri (benzoyloxy) stilbene, 3, 4’, 5-tri (toluyloxy) stilbene and 3, 4’, 5-tri (2”-butenoyloxy) stilbene have been synthesized by esterification process that can further be subjected for biological evaluation. Structures and purities of all newly synthesized derivatives were confirmed by 1H, 13C NMR spectroscopy and infrared spectroscopy.
Document Type
Thesis - unrestricted
Recommended Citation
Pageni, Parasmani, "Synthesis of Ester Derivatives of Resveratrol as Potential Anti-Cancer Drugs" (2013). Electronic Theses and Dissertations. Paper 1181. https://dc.etsu.edu/etd/1181
Copyright
Copyright by the authors.