Honors Program

University Honors

Date of Award

5-2013

Thesis Professor(s)

Yuriy Razskazovskiy

Thesis Professor Department

Physics and Astronomy

Thesis Reader(s)

David M. Close, Scott Kirkby

Abstract

A group of prospective drugs with the aromatic di-N-oxide (ANO) functionality as the common feature are currently undergoing testing for the ability to selectively target tumors surrounded by normal tissues. It has been long recognized that the mechanism of biological activity of these drugs involves DNA damage by free radical species generated through one-electron reduction, although the exact nature of the reactive intermediate responsible for DNA damage remains uncertain. It is believed, however, that one of the key factors defining, in particular, hypoxic selectivity of these drugs is the rate of N-O bond scission in the one-electron reduced intermediate. In this study we have made an attempt to verify whether the predictions made in the literature regarding the N-O bond dissociation rate in a related class of derivatives are applicable to the same process in ANO. For that purpose both theoretical (electronic structure calculations) and experimental (Electron Spin Resonance spectroscopy) have been employed. While our results are not conclusive, they have laid the groundwork for future studies.

Document Type

Honors Thesis - Open Access

Copyright

Copyright by the authors.

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