Non-Occlusive St-Segment Elevated Myocardial Infarction Following the Administration of Liposomal Amphotericin B in the Treatment of Cryptococcal Meningitis
What is known and objective: Liposomal amphotericin B (L-AmB) is the cornerstone of many serious invasive fungal infections. Despite lower frequencies of commonly reported adverse events in clinical trials compared to conventional formulations, post-marketing complications continue to mount. Case description: We present a case of chest pain following the initial dose of L-AmB for cryptococcal meningitis. Electrocardiogram demonstrated no acute electrocardiogram findings. Upon rechallenge, the chest pain worsened was subsequently accompanied by ST-segment elevation. Emergent coronary angiography found no acute findings. What is new and conclusion: Providers should be aware of cardiac complications with L-AmB, including non-occlusive ST-segment elevation.
Kullab, Susan M.; Patel, Paras D.; and Lewis, Paul O.. 2020. Non-Occlusive St-Segment Elevated Myocardial Infarction Following the Administration of Liposomal Amphotericin B in the Treatment of Cryptococcal Meningitis. Journal of Clinical Pharmacy and Therapeutics. Vol.45(5). 1168-1171. https://doi.org/10.1111/jcpt.13109 PMID: 31986219 ISSN: 0269-4727