Neuroprotective and Neurotoxic Roles of Levodopa (L-DOPA) in Neurodegenerative Disorders Relating to Parkinson's Disease
Summary. Despite its being the most efficacious drug for symptom reversal in Parkinson's disease (PD), there is concern that chronic levodopa (L-DOPA) treatment may be detrimental. In this paper we review the potential for L-DOPA to 1) autoxidize from a catechol to a quinone, and 2) generate other reactive oxygen species (ROS). Overt toxicity and neuroprotective effects of L-DOPA, both in vivo and in vitro, are described in the context of whether L-DOPA may accelerate or delay progression of human Parkinson's disease.
Kostrzewa, R. M.; Kostrzewa, J. P.; and Brus, R.. 2002. Neuroprotective and Neurotoxic Roles of Levodopa (L-DOPA) in Neurodegenerative Disorders Relating to Parkinson's Disease. Amino Acids. Vol.23(1-3). 57-63. https://doi.org/10.1007/s00726-001-0110-x PMID: 12373519 ISSN: 0939-4451