Title

Convenient Preparation of 2,7,8-Trimethyl-6-Hydroxychroman-2-Carboxylic Acid (γ-Trolox)

Document Type

Article

Publication Date

1-1-2008

Description

The title chroman is useful in synthesis and as a water-soluble analog of γ-tocopherol, a member of the vitamin E family. This new synthesis of γ-trolox proceeds via selective aromatic demethylation of Trolox, the more easily available 2,5,7,8-tetramethyl homolog compound. This route is shorter than the previous synthesis, avoids the use of cyanide and methoxybutadiene, and requires no chromatography.

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