Title

Synthesis of Iron-Binding Oligonucleotides and Their Reactions With Single-Stranded DNA

Document Type

Article

Publication Date

1-1-1993

Description

Two 12-base oligonucleotides were synthesized and modified by attaching metal-binding ligands (2,6-pyridinedicarboxylate and 2,2′-dipicolylamine) to their 5′-ends. When hybridized to a 135-base single stranded DNA, in the presence of Fe2+, O2, and a reducing agent, these obligonucleotides cleaved the complementary DNA chain with unique and high base-sequence specificities.

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