Title

Macrophage Activation by T Cells: Cognate and Non-Cognate Signals

Document Type

Article

Publication Date

1-1-1993

Description

Both tumor necrosis factor-α and interferon-γ are involved in the activation of macrophage cytocidal/cytostatic effector function. Recent studies provide evidence that, in non-septic inflammatory disease, T cells may activate macrophages primed by interferon-γ either by providing tumor necrosis factor-α (in soluble or membrane-anchored form) or by inducing macrophage tumor necrosis factor-α production by antigen-non-specific cognate interactions. Conversely, T cells may inhibit macrophage activation by producing cytokines that inhibit either tumor necrosis factor-α production or interferon-γ receptor signaling.

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