Localization of NGF Expression in Mouse Spleen and Salivary Gland: Relevance to Pleotropic Functions
Our primary goal was to determine if leukocytes are a source of nerve growth factor (NGF) in mouse spleen. Noradrenergic nerves were localized to arteries and white pulp in normal spleens but only to arteries in ultra-immunodeficient R2G2 mice that lack leukocytes. NGF mRNA was detected in vascular cells and leukocytes of normal spleen, and several of the latter were T cells based on double labeling for NGF mRNA and CD3. Our findings indicate NGF is produced by vascular cells and to a lesser extent by leukocytes in spleen and provide support for pleiotropic actions in spleen and salivary glands.
Britt, Nicholas M.; Poston, Megan D.; Garbe, Chloe G.; Miller, Madeleine K.; Peeters, Loren D.; Wills, Liza J.; Schweitzer, John B.; Brown, Russell W.; and Hoover, Donald B., "Localization of NGF Expression in Mouse Spleen and Salivary Gland: Relevance to Pleotropic Functions" (2022). ETSU Faculty Works. 34.