Physical Dependence in Patient With Chronic Low Back Pain Treated With Topiramate: A Case Report
In the last decade, prescription of anticonvulsants for treatment of low back pain (LBP) increased 4-fold. Among them, topiramate has frequent side effects and a mechanism of action that is not fully understood. The authors describe a 65-year-old woman with dependence on topiramate prescribed for chronic LBP and discuss how she was successfully weaned off topiramate using duloxetine. A significant agonistic effect by topiramate on α-2 adrenergic receptors in the brain likely accounts for the symptoms of withdrawal that were seen. We attribute the resolution of her topiramate withdrawal symptoms to reduced norepinephrine (NE) release, a known effect of duloxetine administration.
Bratton, Roscoe H. and Ward, Sameh A., "Physical Dependence in Patient With Chronic Low Back Pain Treated With Topiramate: A Case Report" (2019). ETSU Faculty Works. 330.