Transgenic Overexpression of CTRP3 Does Not Prevent Alcohol Induced Hepatic Steatosis in Female Mice
Document Type
Article
Publication Date
1-1-2022
Description
Alcoholic liver disease (ALD) is one of the leading causes of morbidity and mortality from hepatic complications. C1q/TNF-related protein 3 (CTRP3) is an adiponectin paralog and, in male mice, increased levels of circulating CTRP3 prevents ALD. Therefore, the purpose of this study was to replicate the observed hepatoprotective effect of elevated circulating CTRP3 levels in female mice. Twelve-week-old female wildtype and CTRP3 overexpressing transgenic mice were fed the Lieber-DeCarli alcohol-containing liquid diet (5% vol/vol) for 6 weeks. Unlike the previous study with male mice, CTRP3 overexpression provided no attenuation to alcohol-induced hepatic lipid accumulation, cytokine production, or overall mortality. In conclusion, there appears to be a clear sex-specific effect of CTRP3 in response to alcohol consumption that needs to be explored further.
Citation Information
Thomas, Kristy L.; Root, Callie L.; and Peterson, Jonathan M., "Transgenic Overexpression of CTRP3 Does Not Prevent Alcohol Induced Hepatic Steatosis in Female Mice" (2022). ETSU Faculty Works. 104.
https://dc.etsu.edu/etsu-works-2/104