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MS (Master of Science)
Date of Award
Committee Chair or Co-Chairs
Michael S. Zavada
Dhirena Kumar, Ranjan N. Chakraborty
ATP synthase is the fundamental means of the cellular energy production in all organisms. Malfunction of ATP synthase is associated with multiple disease conditions. This enzyme is not only implicated in disease conditions but also likely to contribute in new therapies for multiple diseases by being a molecular target for several inhibitors. Bioflavonoids are a class of plant secondary metabolites known to exhibit antioxidants, chemopreventive, and chemotherapeutic properties. Their actual mode of action is not clear; however, some bioflavonoid are known to block the action of enzymes and other substances that promote the growth of cancer cells by binding to the multiple molecular targets in the body including ATP synthase. The most common dietary polyphenol resveratrol was shown to induce apoptosis via mitochondrial pathways and has chemopreventive properties against prostate cancer. Here we report the general inhibitory effects of dietary bioflavonoids on ATP synthase enzyme and intact E. coli cells.
Thesis - restricted
Chinnam, Naga babu, "Inhibition of Escherichia coli ATP Synthase Using Bioflavonoids." (2011). Electronic Theses and Dissertations. Paper 1298. https://dc.etsu.edu/etd/1298
Copyright by the authors.