Nicotinamide Riboside and Beta-hydroxybutyrate Activate Parallel Pathways for C. elegans Lifespan Extension

Faculty Mentor

Dr. Patrick Bradshaw

Mentor Home Department

Biomedical Sciences

Short Abstract

The ketone body beta-hydroxybutyrate primarily extends lifespan of the C.elegans nematode during adulthood through activating the transcriptional regulator DAF-16/FOXO, while nicotinamide riboside, a form of vitamin B3 and NAD+ precursor, extends lifespan in C. elegans primarily during larval development through activating the mitochondrial unfolded protein response. In this study we found that C.elegans lifespan greatly decreased when both compounds were supplemented together. These results have important implications for people on ketogenic or fasting diets who supplement with NAD+ precursors.

Category

Science and Technology

Start Date

24-4-2023 2:30 PM

End Date

24-4-2023 2:45 PM

Location

D.P. Culp Center Room 271J

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Apr 24th, 2:30 PM Apr 24th, 2:45 PM

Nicotinamide Riboside and Beta-hydroxybutyrate Activate Parallel Pathways for C. elegans Lifespan Extension

D.P. Culp Center Room 271J

The ketone body beta-hydroxybutyrate primarily extends lifespan of the C.elegans nematode during adulthood through activating the transcriptional regulator DAF-16/FOXO, while nicotinamide riboside, a form of vitamin B3 and NAD+ precursor, extends lifespan in C. elegans primarily during larval development through activating the mitochondrial unfolded protein response. In this study we found that C.elegans lifespan greatly decreased when both compounds were supplemented together. These results have important implications for people on ketogenic or fasting diets who supplement with NAD+ precursors.