Microglia Activation in Mouse Models of Social Deficits
Faculty Mentor
Dr. Michelle Chandley
Mentor Home Department
Biomedical Sciences
Short Abstract
Microglia are the resident immune cells of the brain. Elevated numbers of activated microglia cells have been shown in neurodevelopmental disorders such as autism spectrum disorder (ASD). This study examines microglia activation in two animal models associated with social behavior deficits—a core behavioral feature of ASD. The microglial marker, IBA-1, was quantified using immunohistochemistry in the hippocampal region of the mouse brain. No evidence of microglial activation was found in either model when compared to control wild-type mice.
Category
Science and Technology
Start Date
24-4-2023 11:45 AM
End Date
24-4-2023 12:00 PM
Location
D.P. Culp Center Room 219
Microglia Activation in Mouse Models of Social Deficits
D.P. Culp Center Room 219
Microglia are the resident immune cells of the brain. Elevated numbers of activated microglia cells have been shown in neurodevelopmental disorders such as autism spectrum disorder (ASD). This study examines microglia activation in two animal models associated with social behavior deficits—a core behavioral feature of ASD. The microglial marker, IBA-1, was quantified using immunohistochemistry in the hippocampal region of the mouse brain. No evidence of microglial activation was found in either model when compared to control wild-type mice.