Inhibitory effects of Proteus on Pseudomonas aeruginosa's Pyocyanin communication system

Abstract

How different microorganisms interact with each other are an understudied area of research. Microbes are extremely social and display different interactions ranging from mutualistic to antagonistic behaviors towards one another. The current research we present, focuses on the microbial interaction between Proteus mirabilus and Pseudomonas aeruginosa. We believe that Proteus mirabilis and potentially other members of the Proteus genus are capable of producing a compound that inhibits the secretion and use of pyocyanin, a quorum-sensing molecule used by Pseudomonas aeruginosa. This secreted compound has resulted in changes in the amount of pyocyanin produced, the motility of P. aeruginosa, and general disruption in the ability of P. aeruginosa to communicate from bacteria to bacteria within the colony. The results from this research may help to better understand polymicrobial interactions and provide potential options for controlling the virulence of P. aeruginosa as well as offering new therapeutic options for infections.

Start Time

16-4-2025 11:00 AM

End Time

16-4-2025 12:00 PM

Room Number

219

Presentation Type

Oral Presentation

Presentation Subtype

UG Orals

Presentation Category

Health and STEM

Faculty Mentor

Sean Fox

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Apr 16th, 11:00 AM Apr 16th, 12:00 PM

Inhibitory effects of Proteus on Pseudomonas aeruginosa's Pyocyanin communication system

219

How different microorganisms interact with each other are an understudied area of research. Microbes are extremely social and display different interactions ranging from mutualistic to antagonistic behaviors towards one another. The current research we present, focuses on the microbial interaction between Proteus mirabilus and Pseudomonas aeruginosa. We believe that Proteus mirabilis and potentially other members of the Proteus genus are capable of producing a compound that inhibits the secretion and use of pyocyanin, a quorum-sensing molecule used by Pseudomonas aeruginosa. This secreted compound has resulted in changes in the amount of pyocyanin produced, the motility of P. aeruginosa, and general disruption in the ability of P. aeruginosa to communicate from bacteria to bacteria within the colony. The results from this research may help to better understand polymicrobial interactions and provide potential options for controlling the virulence of P. aeruginosa as well as offering new therapeutic options for infections.