Honors Program

Midway Honors, Honors in Chemistry

Date of Award

5-2017

Thesis Professor(s)

Douglas Thewke

Thesis Professor Department

Biochemistry and Molecular Biology

Thesis Reader(s)

Karen Kornweibel, Antonio Rusinol

Abstract

Vascular calcification is strongly correlated with the clinical manifestations of atherosclerosis, heart attacks and strokes. The calcification process resembles bone formation and involves the osteogenic trans-differentiation of smooth muscles cells within the arterial wall. Cannabinoid receptors are known to modulate bone formation and are present in atherosclerotic vessels, suggesting they may also play a role in modulating calcification. Therefore, we evaluated the effects of cannabinoids on the expression of osteogenic proteins by vascular smooth muscle cells undergoing calcification.

Publisher

East Tennessee State University

Document Type

Honors Thesis - Withheld

Creative Commons License

Creative Commons License
This work is licensed under a Creative Commons Attribution-Noncommercial-No Derivative Works 3.0 License.

Copyright

Copyright by the authors.

Available for download on Sunday, April 14, 2019

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