Honors Program
Honors in Mathematics
Date of Award
12-2015
Thesis Professor(s)
Michele Joyner
Thesis Professor Department
Mathematics and Statistics
Thesis Reader(s)
Michele Joyner, Ariel Cintron-Arias, Charlotte Powers
Abstract
Vancomycin is an antibiotic used for the treatment of systemic infections. It is given
intravenously usually every twelve or twenty-four hours. This particular drug has a
medium level of boundedness, with approximately fty percent of the drug being free
and thus physiologically eective. A physiologically-based pharmacokinetic (PBPK)
model was used to better understand the absorption, distribution, and elimination of
the drug. Using optimal parameters, the model could be used in the future to test
how various factors, such as BMI or excretion levels, might aect the concentration
of the antibiotic.
Document Type
Honors Thesis - Open Access
Creative Commons License
This work is licensed under a Creative Commons Attribution-Noncommercial-No Derivative Works 3.0 License.
Recommended Citation
White, Rebekah, "A Physiologically-Based Pharmacokinetic Model for Vancomycin" (2015). Undergraduate Honors Theses. Paper 308. https://dc.etsu.edu/honors/308
Copyright
Copyright by the authors.
Included in
Ordinary Differential Equations and Applied Dynamics Commons, Other Applied Mathematics Commons