Honors Program

Honors in Mathematics

Date of Award

12-2015

Thesis Professor(s)

Michele Joyner

Thesis Professor Department

Mathematics and Statistics

Thesis Reader(s)

Michele Joyner, Ariel Cintron-Arias, Charlotte Powers

Abstract

Vancomycin is an antibiotic used for the treatment of systemic infections. It is given

intravenously usually every twelve or twenty-four hours. This particular drug has a

medium level of boundedness, with approximately fty percent of the drug being free

and thus physiologically eective. A physiologically-based pharmacokinetic (PBPK)

model was used to better understand the absorption, distribution, and elimination of

the drug. Using optimal parameters, the model could be used in the future to test

how various factors, such as BMI or excretion levels, might aect the concentration

of the antibiotic.

Document Type

Honors Thesis - Open Access

Creative Commons License


This work is licensed under a Creative Commons Attribution-Noncommercial-No Derivative Works 3.0 License.

Copyright

Copyright by the authors.

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