Honors Program

Honors in Mathematics

Date of Award


Thesis Professor(s)

Michele Joyner

Thesis Professor Department

Mathematics and Statistics

Thesis Reader(s)

Michele Joyner, Ariel Cintron-Arias, Charlotte Powers


Vancomycin is an antibiotic used for the treatment of systemic infections. It is given

intravenously usually every twelve or twenty-four hours. This particular drug has a

medium level of boundedness, with approximately fty percent of the drug being free

and thus physiologically eective. A physiologically-based pharmacokinetic (PBPK)

model was used to better understand the absorption, distribution, and elimination of

the drug. Using optimal parameters, the model could be used in the future to test

how various factors, such as BMI or excretion levels, might aect the concentration

of the antibiotic.

Document Type

Honors Thesis - Open Access

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