MS (Master of Science)
Date of Award
Committee Chair or Co-Chairs
Darrell J. Moore, Michael L. Woodruff, Ronald H. Baisden
Fetal Alcohol Syndrome (FAS) labels children with physical, mental and behavioral deficits exposed to alcohol in utero. Current research indicates that timing of alcohol exposure of the embryo/fetus is a critical determinant of the behavioral deficits associated with FAS. This study represents a model for binge drinking, in which C57BL mouse embryos were exposed to alcohol during 2 separate critical periods of brain development, gestational day (GD) 7 or 8. As adults, the offspring were tested to determine if loco-motor activity and emotional reaction to a novel environment had been affected. Significant differences due to treatment and sex were noted for both the number of urinations (p=.005 and .001, respectively) and fecal boli (p=.011 and .001, respectively). These results suggest that the quantity of alcohol exposure in utero on the developing brain as in this binge-drinking model is critical in terms of adverse effects on behavioral outcome for the offspring.
Thesis - Open Access
Nunley, Kevin Wade, "Behavioral Changes in Adult C57BL/6J Mice following Prenatal Exposure to Ethanol." (2001). Electronic Theses and Dissertations. Paper 46. http://dc.etsu.edu/etd/46
Copyright by the authors.