Degree Name
MS (Master of Science)
Program
Biology
Date of Award
12-2001
Committee Chair or Co-Chairs
Foster Levy, Elaine Walker
Committee Members
Laraine Powers
Abstract
Antimicrobial susceptibility profiles were assembled for isolates of Moraxella catarrhalis collected from the Mountain Home Veteran's Affairs Medical Center (VAMC) clinical laboratory in Johnson City, Tennessee. The goal of the study was to identify isolates for genetic characterization using comparisons of susceptibility profiles. Isolates of Moraxella catarrhalis collected from July 1984 through 1994 were analyzed for β-lactamase production using a Cefinase disk assay.
A multi-drug profile consisting of 11 β-lactam antibiotics was performed on the 41 M. catarrhalis isolates. Kirby Bauer disk assays were performed for 7 cephalosporin and 4 non-cephalosporin antibiotics.
In summary, 2 observations implicate more complex resistance determinants than the 2 known forms of the BRO β-lactamase. First, there was overlap in the ranges of inhibition zones. Second, several isolates had antibiotic-specific deviations from typical profiles. These data suggest either more variation in the M. catarrhalis BRO β-lactamase than described or contributions to resistance from undescribed determinants.
Document Type
Thesis - unrestricted
Recommended Citation
Taylor, LaShan Denise, "Antibiotic Resistance: Multi-Drug Profiles and Genetic Determinants." (2001). Electronic Theses and Dissertations. Paper 43. https://dc.etsu.edu/etd/43
Copyright
Copyright by the authors.