MS (Master of Science)
Date of Award
Committee Chair or Co-Chairs
Yu-Lin Jiang, Chu-Ngi Ho
The interaction of 4-(1'-[8'-(1''-pyrenyl)naphthyl])-2,6-diaminopyridine bis-glycamide bishydrocholride known to have anticancer properties with deoxyribonucleic acid (DNA) had been studied on a modified gold electrode by self-assembled monolayer using cyclic voltammetry. K4Fe (CN)6 was used as a probe to obtain electrochemical information on the electrode surface.
A bare gold (Au) electrode was modified with cysteamine and our results showed no change in the limiting steady state current as compared to the bare Au electrode. There was a reduction in the steady state current after the modification of the gold electrode with DNA. Immobilization of the DNA modified gold electrode with the anticancer compound also revealed a further reduction in the steady state current. The reduction in the steady state current is attributed to the receptor and DNA forming a nonelectrochemical complex due to the intercalation of the receptor and DNA on the gold electrode surface.
Thesis - Open Access
Kamasah, Alexander, "Using Electrochemical Method to Study the Interaction Between DNA and a compound Known to Have Anticancer Property." (2011). Electronic Theses and Dissertations. Paper 1379. http://dc.etsu.edu/etd/1379
Copyright by the authors.