Degree Name

MS (Master of Science)

Program

Chemistry

Date of Award

12-2011

Committee Chair or Co-Chairs

Peng Sun

Committee Members

Yu-Lin Jiang, Chu-Ngi Ho

Abstract

The interaction of 4-(1'-[8'-(1''-pyrenyl)naphthyl])-2,6-diaminopyridine bis-glycamide bishydrocholride known to have anticancer properties with deoxyribonucleic acid (DNA) had been studied on a modified gold electrode by self-assembled monolayer using cyclic voltammetry. K4Fe (CN)6 was used as a probe to obtain electrochemical information on the electrode surface.

A bare gold (Au) electrode was modified with cysteamine and our results showed no change in the limiting steady state current as compared to the bare Au electrode. There was a reduction in the steady state current after the modification of the gold electrode with DNA. Immobilization of the DNA modified gold electrode with the anticancer compound also revealed a further reduction in the steady state current. The reduction in the steady state current is attributed to the receptor and DNA forming a nonelectrochemical complex due to the intercalation of the receptor and DNA on the gold electrode surface.

Document Type

Thesis - Open Access

Copyright

Copyright by the authors.

Included in

Chemistry Commons

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