Degree Name

MS (Master of Science)

Program

Chemistry

Date of Award

5-2011

Committee Chair or Co-Chairs

Yu-Lin Jiang

Committee Members

Aleksey N. Vasiliev, Ismail O. Kady

Abstract

Recently, the compound resveratrol has had media attention as an anti carcinogen. However, the bioavailability of resveratrol is low in the human system due to its hydrophobic nature. Therefore, it must be administered in high dosages to be effective. A plethora of derivatives have been synthesized that have the potential of resveratrol but sadly share low bioavailability. The first effort of this research was an attempt to produce a more hydrophilic ester of resveratrol. Failing this, the final product was synthesized using a glycine derivative to produce 4-[(1E)-2-(3,5-diacetyloxyphenyl)ethenyl]phenyl N-[(1,1-dimethylethoxy)carbonyl]-glycinate.

Document Type

Thesis - Open Access

Copyright

Copyright by the authors.

Share

COinS