MS (Master of Science)
Date of Award
Committee Chair or Co-Chairs
Aleksey N. Vasiliev, Ismail O. Kady
Recently, the compound resveratrol has had media attention as an anti carcinogen. However, the bioavailability of resveratrol is low in the human system due to its hydrophobic nature. Therefore, it must be administered in high dosages to be effective. A plethora of derivatives have been synthesized that have the potential of resveratrol but sadly share low bioavailability. The first effort of this research was an attempt to produce a more hydrophilic ester of resveratrol. Failing this, the final product was synthesized using a glycine derivative to produce 4-[(1E)-2-(3,5-diacetyloxyphenyl)ethenyl]phenyl N-[(1,1-dimethylethoxy)carbonyl]-glycinate.
Thesis - Open Access
Van Cleve, Shelley Marie, "Synthesis of a Resveratrol Glycinate Derivative." (2011). Electronic Theses and Dissertations. Paper 1312. http://dc.etsu.edu/etd/1312
Copyright by the authors.